The cees dekker Diaries
The cees dekker Diaries
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Using single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
, Groningen researchers current the outcome in their initiatives for making labs extra sustainable and supply guidelines for other labs.
2007, to start with genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is actually a remarkably flexible protein composition; and 1st detection of DNA knots utilizing nanopores
The coiled-coil with the human Rad50 DNA repair service protein has certain segments of amplified adaptability
We form microorganisms into kinds that deviate from their organic phenotype. Especially, I will show our power to condition Stay E. coli microbes into novel designs for example rectangles, squares, triangles and circles.
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
‘Yes, I understand individuals had been shocked at time. At the end of the nineties, when I was in my forties, I was Professor of Molecular Electronics and I have to admit that it experienced turn into a bit bored, I didn’t discover A lot anymore. The sector went more into the applying facet, how you could possibly combine nanotubes into electronic circuits.
‘The fantastically delicate way by which elements in nature operate hardly ever ceases to amaze me. If we resolve the puzzle of how daily life arrived into staying, I anticipate that my amazement on the complexity of development can have greater and with it my awe with the greatness from the Creator.’
Considering that 2000 he moved to one-molecule biophysics and nanobiology, with study from scientific studies of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Far more lately his analysis has focused on finding out chromatin construction and mobile division with micro organism on chip, whilst he can also be attempting to finally Establish artificial cells from The underside up.
2001, discovery of single-electron transistors at space temperature determined by nanotubes; realization of 1st logic circuits with carbon nanotube equipment; and discovery in the molecular composition of DNA mend enzymes with AFM
2008, 1st observation of protein-coated DNA translocation by means of nanopores; resolved the origin of the electrophoretic ceesdekker.net power on DNA in nanopores; learned an important velocity maximize of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes